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Cahaba River NWR is one of nation's newest National Wildlife Refuges, the 540th in fact. Established September 25, 2002 for the purpose of protecting and managing a unique section of the Cahaba River and land adjacent to it. Cahaba River NWR is home to five federally listed species including the Cahaba shiner, goldline darter, round rocksnail, and cylindrical lioplax snail.

Cahaba River NWR is located in Bibb County, Alabama, approximately six miles east of West Blockton on County road 24. River access is provided by a gravel road on the south (right) side of Bibb County Road 24 approximately 250 yards past the refuge entrance sign.

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The largest known stand of the imperiled shoals lily (known locally as the Cahaba lily) also occurs within the Refuge. During summer months, this beautiful plant blooms and people come from across the region to view this magnificent display of nature. There is even an annual Cahaba lily festival that draws thousands of visitors to the area the last Saturday in May.